HLA-E and B-cell chronic lymphocytic leukemia: Our study revealed that lymph node-mimicking CLL spheroids without T cells lacked the increase in HLA-E expression on the surface of tumour cells compared to T cell-containing CLL spheroids, suggesting that the presence of T cells impairs NK cell-mediated ADCC within the lymph node microenvironment via the HLA-E:NKG2A axis.