In the presence of multiple concentrations of rituximab, CD40L, and IL-4 significantly decreased specific lysis against Ramos (Fig. 2a and b), Raji (Fig. 2c) and SU-DHL-6 (Fig. 2d) NHL cell lines, as well as against primary CLL (Fig. 2e). This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.