Mutations/indels Solid cancer kit (BRAF, EGFR, KRAS, NRAS and PIK3CA)Breast cancer kit (AKT1, ERBB2, ESR1, KRAS, PIK3CA and TP53)NSCLC kit (EGFR, KRAS, BRAF and PIK3CA)Colorectal cancer kit (KRAS, NRAS, BRAF and PIK3CA). The gene discussed is ESR1; the disease is colorectal cancer.