Both GABRB2 and ERBB4 play pivotal roles in regulating key neurotransmitter systems, namely Gamma-Aminobutyric Acid (GABA), glutamate, dopamine, and neuregulin-1 (NRG1) signaling, all of which are central to the neurobiological mechanisms underlying schizophrenia (Tsang et al., 2013, Banerjee et al., 2010). The gene discussed is ERBB4; the disease is schizophrenia.