LGMN and Parkinson disease: In a study using a rotenone-induced PD mouse model, combined with antibiotic-induced microbiome depletion and fecal microbiota transplantation, it was found that gut microbiota dysbiosis, along with leaky gut-induced bacterial endotoxins, activates C/EBPβ/AEP signaling and α-syn pathology, ultimately leading to neurodegeneration in PD (52).