This decline is manifested as protein homeostasis collapse within neurons and exacerbation of neurodegeneration in mouse models of Alzheimer’s disease, emphasizing the importance of the DHHC5-Beclin1 pathway in maintaining cellular homeostasis in aging-related diseases (especially neurodegenerative diseases), and providing potential targets for intervention (such as targeting DHHC5 or Beclin1 palmitoylation) (39). Here, BECN1 is linked to early-onset autosomal dominant Alzheimer disease.