NF-κB subsequently drives the expression of immunosuppressive genes (e.g., IL-10, TGF-β), directly inhibiting CD8+ T cell activity. High-fat diet or decitabine treatment exacerbates AML immunosuppression through this mechanism, while statins can reverse resistance by blocking CD36-mediated signaling (201). The gene discussed is CD36; the disease is acute myeloid leukemia.