Similarly, palmitoylation at cysteine residues C104/C107 of Claudin 4 (CLDN4) in hepatocellular carcinoma (HCC) stabilizes its lipid raft anchoring by inhibiting clathrin-mediated endocytosis, activating the Notch pathway to drive lenvatinib resistance (226). Here, CLDN4 is linked to hepatocellular carcinoma.