In Shh-expressing HEK293a and A549 NSCLC cells, Hhat knockdown impairs juxtacrine/paracrine signaling to C3H10T1/2 and Shh-Light2 reporter cells, underscoring Hhat’s critical role in Hh-dependent tumorigenesis (179). The gene discussed is HHAT; the disease is non-small cell lung carcinoma.