PIEZO1 and cancer: Our focus on LIHC and STAD models for PIEZO1 expression analysis was driven by their dual significance as leading causes of cancer-related mortality in China with high incidence and poor prognosis, coupled with their development within mechanoactive microenvironments (e.g., hepatic sinusoidal shear stress, gastric peristalsis) where PIEZO1’s mechanosensory function may prove pivotal.