As for PFI, elevated PIEZO1 expression was associated with poorer OS in 7 cancer types, including, ACC (HR = 2.917, 95% CI: 1.512-5.629, p = 0.0014), CESC (HR = 1.986, 95% CI: 1.227-3.212, p = 0.0052), COAD (HR = 1.441, 95% CI: 1.016-2.043, p = 0.0403), LGG (HR = 1.445, 95% CI: 1.098-1.902, p = 0.0087), LUSC (HR = 1.455, 95% CI: 1.048-2.018, p = 0.0250), MESO (HR = 1.724, 95% CI: 1.020-2.914, p = 0.0420), PAAD (HR = 1.588, 95% CI: 1.076-2.344, p = 0.0199) (Figure 2C). This evidence concerns the gene PIEZO1 and adrenal cortex carcinoma.