In conclusion, regulated levels of proinflammatory cytokine (20) and chemokine during E. coli infection in IL-27 receptor KO neonatal mice, retains CXCR2 expression on the splenic monocyte which causes effective migration to the site of infection and is consistent with effective bacterial clearance and tissue homeostasis. The gene discussed is CXCR2; the disease is escherichia coli infection.