CHRNA7 and serum lipopolysaccharide activity: Beyond cytokine regulation, recent in vivo model of endotoxemia have demonstrated a distinct role for α7nAChR in regulating immune cell trafficking: α7nAChR deficiency markedly impairs macrophage recruitment to inflamed organs, including lungs and liver, by downregulating key integrins such as αMβ2, thereby limiting integrin-mediated migration (101).