In the context of atherosclerosis, inflammatory cues such as LPS/TLR4 signaling, local acidosis, and endogenous lipid mediators, including capsaisin, anandamide (AEA) and N-arachidonoyl dopamine (NADA), sensitize TRPV1 channels expressed on perivascular sensory afferents (85–87). This evidence concerns the gene TRPV1 and atherosclerosis.