A recent study reported that hemokine (C-C motif) receptor 8 (CCR8) is highly expressed on effector tumor-infiltrating regulatory T cells (TI-Tregs), but its expression remains relatively low on peripheral Tregs and conventional T cells in both mice and humans, rendering CCR8 an ideal candidate for the selective targeting of TI-Tregs (35). Here, CCR8 is linked to neoplasm.