In N+ gastric cancer, leptin-induced phosphorylation of angiopoietin-like protein 4 (ANGPTL4) enhances lipid uptake via overexpressed lipoprotein lipase (LPL), thereby stimulating prostaglandin E2 (PGE2) production and ultimately facilitating lymph node metastasis (57). This evidence concerns the gene ANGPTL4 and gastric cancer.