PRF1 and gastric cancer: THBS1 enhances the cytotoxic activity of Vγ9Vδ2 T cells against gastric cancer cells via an m6A-dependent activation of the RIG-I-like Receptor (RLR) Signaling Pathways, concomitantly upregulating Interferon-γ (IFN-γ), Interferon-α (IFN-α), perforin and granzyme B. Recent studies have also shown that circMAN1A2 in exosomes derived from gastric cancer cells is highly expressed.