When FL/GM-DCs loaded with B16-OVA tumor lysates were co-cultured with CD4+T cells that had been isolated from OT-II mice (Figure 4h), we detected a significant increase in the activation and proliferation of CD44+CD4+T cells relative to those co-cultured with GM/IL4-DCs (37% vs. 25.5%) (Figure 4j). The gene discussed is CD4; the disease is neoplasm.