Given the established roles of Notch1 in NSCLC proliferation, migration, and tumor immunity (27, 28), along with its capacity to induce Akt phosphorylation (p-Akt) (21), we investigated the involvement of the Notch1/Akt pathway in CRTC1-mediated regulation. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.