In contrast, the FPR3/NFATc1/NOTCH3 axis (145) exerts tumor-suppressive effects in diffuse-type GC by modulating calcium flux: FPR3 activation restricts NFATc1 nuclear translocation, downregulating NOTCH3-AKT/mTOR signaling and suppressing stemness. The gene discussed is AKT1; the disease is gastric cancer.