We investigated the expression of TG2 in 163 human peritoneal membrane tissue samples, including controls, tissues exposed to conventional acidic or low‐glucose degradation product (GDP) pH‐neutral solutions, and those with peritonitis or encapsulating peritoneal sclerosis (EPS), and explored the role of TG2 in high‐glucose–induced pathophysiology in mesothelial cells. This evidence concerns the gene TGM2 and peritonitis.