TGM2 and Peritoneal Fibrosis: Thus, TG2 contributes to disease progression in fibrosis and cancer (Collighan & Griffin, 2009; Soltani & Kaartinen, 2023; Tatsukawa & Hitomi, 2021), suggesting that TG2 is a key enzyme in the pathogenesis of peritoneal fibrosis and increases collagen density during PD treatment.