The analysis of murine genes revealed 489 upregulated genes with |log2 (FoldChange)|≥1 and P<0.05, including Cxcl13, matrix metallopeptidase 3 (Mmp3) and serum amyloid A1 (Saa1), all of which are associated with RA (Vallon et al., 2001; Bechman et al., 2020) (Fig. S3A and Table S9). The gene discussed is MMP3; the disease is rheumatoid arthritis.