PTK2 and glioblastoma: Injury response GBM stem cells map to the mesenchymal-like and glycolytic/plurimetabolic cell states, while developmental GBM stem cells, which are much less dependent on integrin signalling and FAK, map to non-mesenchymal-like cell states, such as ‘neural precursor’, ‘astrocytic’ and ‘oligodendrocyte progenitor’-like (Richards et al., 2021; MacLeod et al., 2024).