FAK is implicated in mechanotransduction – by connecting signals from the integrin family of ECM adhesion receptors to the actin cytoskeleton – and actomyosin contractility (Di et al., 2023); this has been shown to regulate the switch between epithelial-like and mesenchymal-like colon cancer cells (Avizienyte and Frame, 2005). Here, PTK2 is linked to colonic neoplasm.