MAPT and Alzheimer disease: 2022). In early‐stage AD, the initial accumulation of tau is observed in the entorhinal cortex, which subsequently spreads to the hippocampus. The hippocampus is then functionally disconnected from other brain regions because of the loss of hippocampal tissue. In the advanced stages of the disease, there is a breakdown in communication between the dentate gyrus and other subfields of the hippocampus, leading to cognitive deficiencies (Y. L. Rao et al. 2022).