TNFRSF1B and neoplasm: Taken together, our data support the hypothesis that tumors take advantage of two dependent mechanisms, namely (i) TNF production by various types of tumor‐infiltrating immune cells, favoring tumor growth per se, and (ii) the interplay between (tm)TNF and TNFR2+ Tregs with high suppressive activity, making the tumor microenvironment hostile against the antitumor immunity.