First, during acute migraine episodes, the activation of the trigeminovascular system leads to the release of neuropeptides such as CGRP and substance P. These mediators not only trigger mast cell degranulation but also facilitate the migration of monocytes toward the meninges, potentially causing a transient reduction in circulating monocytes and a compensatory elevation in LMR (Eftekhari et al. This evidence concerns the gene TAC1 and migraine disorder.