ERN1 and neoplasm: Blockade of IRE1 significantly reduced tumor weight alone or in the context of chemotherapy (1.019 ± 0.23; Control vs. 0.8039 ± 14; IRE1M) and Western diet‐fed mice (1.112 ± 0.2304; IRE1M; 1.029 ± 0.2275; IRE1M + DOX).