BCL2 and Alzheimer disease: In addition, we observed by RT-qPCR that in both isocortex and hippocampal region of this mouse model, the ratio between mRNA levels of the pro-apoptotic gene Bax over the anti-apoptotic gene Bcl-2 increase in the brain of the 3xTg-AD mice relative to wt mice (Figs. 1G and EV1D).