In this study, we performed in-silico transcriptomic data mining to analyze RCN1 expression at mRNA and protein levels using large publicly available databases and conducted the first large-scale cohort study on the impact of RCN1 in ccRCC, including data from 306 patients who underwent tumor resection at the Clinic of Urology, University Hospital Bonn. This evidence concerns the gene RCN1 and nonpapillary renal cell carcinoma.