In addition, mutation of human VCP associated with degenerative disorders such as IBMPFD (Inclusion body myopathy with early onset Paget disease and frontotemporal dementia) (29), familial ALS (amyotrophic lateral sclerosis) (30), and Charcot-Marie-Tooth disease (31). This evidence concerns the gene VCP and inclusion body myopathy with Paget disease of bone and frontotemporal dementia.