However, NfM and NfL were significantly increased in FTD vs CTRL (p < 0.0001, NfM: r = 0.71, NfL: r = 0.64, large effect) and AD vs CTRL (NfM: p < 0.0001, r = 0.57, large effect; NfL: p = 0.0001, r = 0.41, moderate effect), whereas NfH values revealed no significant difference. Here, NEFL is linked to Alzheimer disease.