Building on the shared immune features between vitiligo and immunotherapy‐responsive tumors—including elevated CD8+ T cell infiltration, IFN‐γ pathway activation, antigen presentation upregulation, and chemokine‐mediated T cell recruitment—we hypothesized that immune gene programs active in vitiligo may serve as indicators of a T cell–inflamed tumor microenvironment (TME). Here, IFNG is linked to neoplasm.