Remarkably, Fulvestrant and Motolimod were able to enhance the immunotherapy response and extend the lifespan of the treated animals (Figure 3C–H; Figure S5C,D, Supporting Information), while Cobicistat combined with anti‐PDL1 did not reduce tumor growth at treatment period and finally extend the lifespan of treated animals compared with anti‐PDL1 group (Figure S5E–H, Supporting Information). The gene discussed is CD274; the disease is neoplasm.