TMEM258 and colorectal carcinoma: For example, MR results suggested a protective effect of higher TMEM258 expression on female-specific CRC risk in CD4 naïve cells (OR = 0.89, confidence interval (CI) = 0.85–0.93) and TN cells at rest (OR = 0.89, CI = 0.85–0.93) but not on male-specific CRC risk.