FADS2, which encodes the enzyme fatty acid desaturase 2, plays a crucial role in the biosynthesis of polyunsaturated fatty acids (PUFAs), including omega-3 and omega-6 fatty acids.27 While omega-3 PUFAs have been shown to have protective associations against various cancers, including CRC, the relationship between omega-6 PUFAs and CRC risk remains unclear.28–31 We found evidence for a protective effect of FADS2 expression on male CRC risk in naïve T cells producing interferon-gamma (IFN) upon activation (TN IFN) 5 days post-activation (OR = 0.89, CI = 0.85–0.93). This evidence concerns the gene IFNG and colorectal carcinoma.