Of the 61 genes with evidence for an association between their expression and CRC risk, 6 had evidence for a shared signal with CRC risk (H4 > 0.8): FADS2, FHL3, HLA-DRB1, HLA-DRB5, RPL28, and TMEM258 (Table 1; full results in Table S4). The gene discussed is HLA-DRB5; the disease is colorectal carcinoma.