Within a single tumor, different cell states co-exist: highly differentiated, proliferative melanocytic cells, which are associated with high MITF levels, whereas slow-cycling, dedifferentiated, invasive stem-like cells correlate with low MITF levels (Arozarena and Wellbrock, 2019; Carreira et al, 2006; Cheli et al, 2011; Hoek et al, 2008; Müller et al, 2014; Popovic and Tartare-Deckert, 2022; Rambow et al, 2019; Tirosh et al, 2016; Tsoi et al, 2018; Wouters et al, 2020). Here, MITF is linked to neoplasm.