The transcriptional co-activator YAP, known to translocate into the nucleus in response to ECM stiffening in various cell types (Cai et al, 2021; Dupont et al, 2011; Huang et al, 2022; Miskolczi et al, 2018), promotes MITF expression in uveal and cutaneous melanoma cells (Barbosa et al, 2023; Miskolczi et al, 2018) and serves as MITF cofactor in uveal melanoma (Barbosa et al, 2023). Here, MITF is linked to uveal melanoma.