Considering that MITF-dependent gene expression overlapped with transcriptional programs involved in melanocyte development, and that these programs were downregulated in MCs cultured on FN (Fig. 5A), we extended our analysis to gene expression signatures associated with melanoma plasticity and differentiation states (Arozarena and Wellbrock, 2019; Durand et al, 2024; Huang et al, 2021; Konieczkowski et al, 2014; Pessoa et al, 2021; Rambow et al, 2015, 2019; Tsoi et al, 2018). This evidence concerns the gene FN1 and melanoma.