Given that YAP is a transcriptional co-activator known to translocate into the nucleus in response to ECM stiffening in various cell types, including melanoma cells (Miskolczi et al, 2018), and that YAP may serve as a potential MITF partner in uveal melanoma cells (Barbosa et al, 2023), we wondered whether YAP could be associated with the observed ECM-dependent MC phenotypes. The gene discussed is MITF; the disease is melanoma.