<h4>Purpose</h4>This study evaluates and compares the effects of continuous and interval training on inflammatory and adhesion molecules in subjects with Type 1 diabetes mellitus (T1D) and healthy controls.<h4>Methods</h4>Using Luminex X-MAP, serum inflammatory and adhesion molecules were measured in 50 non-obese, sedentary adults (78% women; mean age 34 years), including 27 with T1D and 23 healthy controls.<h4>Results</h4>Subjects with T1D exhibited a tendency towards decreased interleukin 10 (IL-10) levels and increased intercellular adhesion molecule (ICAM1) levels compared to controls. This evidence concerns the gene IL10 and diabetes mellitus.