DLG4 and attention deficit-hyperactivity disorder: However, CNs from ADHD patients showed an altered developmental pattern, characterised by changes in extracellular glutamate and decreased transcription of NEUN, PSD95 and EEAT2. Moreover, a significant ~50% reduction in vGLUT2 transcription was observed at multiple time points, suggesting a robust cellular disease endophenotype which might be suitable for future drug screening.