SHMT2 and acute myeloid leukemia: NSUN2 also methylates mRNAs, where m5C stabilizes transcripts encoding key metabolic enzymes, including PHGDH and SHMT2, which are essential for serine/glycine biosynthesis and are implicated in acute myeloid leukemia (AML) progression and leukemic stem cell (LSC) self-renewal [54].