We identified molecular alterations specific to tCLL, which involved several cancer hallmarks signaling pathways (TNF-α, IL-2/STAT5, IL-6/JAK/STAT3, and PI3K-AKT) and metabolic processes that may affect apoptosis, cell proliferation, survival, antibody production, response to the microenvironment, homing and migration, and potentially drug resistance. This evidence concerns the gene IL2 and cancer.