TNF and cancer: We identified molecular alterations specific to tCLL, which involved several cancer hallmarks signaling pathways (TNF-α, IL-2/STAT5, IL-6/JAK/STAT3, and PI3K-AKT) and metabolic processes that may affect apoptosis, cell proliferation, survival, antibody production, response to the microenvironment, homing and migration, and potentially drug resistance.