The first group comprised alterations with non-linear age-frequency distribution, which included three most common AML-associated gene mutations, that is, mutations in the NPM1 and DNMT3A genes and FLT3 internal tandem duplication (FLT3-ITD), FLT3 tyrosine kinase domain mutations (FLT3-TKD), NRAS and EZH2 mutations and mutations affecting the cohesin complex genes (RAD21, SMC1A, SMC3, SF3B1, STAG2). This evidence concerns the gene SMC3 and acute myeloid leukemia.