We also determined that the frequencies of CD45RA+ (generally naïve) and CD45RO+ (generally memory) CD4 (Fig. 2B) and CD8 (Fig. 2C) T cells in the peripheral blood revealed no dramatic changes between non-CF control and CF samples, suggesting the distribution of naïve and memory T cell populations in the peripheral blood is unaltered in people with CF. The gene discussed is CD4; the disease is cystic fibrosis.