In this study, we show that 3 cytokines, IL-13, IL-17, and the TNF family molecule LIGHT, can integrate their signals to define or exaggerate these inflammatory transcriptional phenotypes, and by analyzing gene expression in lung fibroblasts from patients with ILD we find evidence of the transcriptional signatures of these cytokines alone or together in subsets of fibroblasts. Here, TNFSF14 is linked to interstitial lung disease.