In summary, these results show that although the total upregulated transcripts induced by LIGHT, IL-13, IL-17, or their combinations in healthy lung fibroblasts do not associate directly with any one transcriptional phenotype seen in lung fibroblasts from ILD patients, there are signatures of the activities of these cytokines, either alone or in combination, that can be found specifically in several ILD fibroblast subtypes. The gene discussed is IL13; the disease is interstitial lung disease.