From transcripts upregulated by IL-13 alone or in combination with LIGHT (circled, Fig. 6E), a number encoding inflammatory regulatory molecules additionally were associated with ILD fibroblast cluster 12 and to an extent cluster 11, such as FST, LOXL3, LDLR, ADAMTS12, IL1RL1, CITED2, IL17RA, and SERPINB6, although several transcripts were also expressed in other ILD clusters. The gene discussed is SERPINB6; the disease is interstitial lung disease.