Most importantly, we find that LIGHT can cooperate and synergize with both IL-13 and IL-17 to enhance and exacerbate transcriptional phenotypes that relate to proliferation of lung fibroblasts as well as their potential to exhibit inflammatory molecules that could be relevant for several lung diseases, including ILD, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma. This evidence concerns the gene IL13 and interstitial lung disease.