In summary, these results show that although the total upregulated transcripts induced by LIGHT, IL-13, IL-17, or their combinations in healthy lung fibroblasts do not associate directly with any one transcriptional phenotype seen in lung fibroblasts from ILD patients, there are signatures of the activities of these cytokines, either alone or in combination, that can be found specifically in several ILD fibroblast subtypes. This evidence concerns the gene TNFSF14 and interstitial lung disease.