Of the 22 transcripts that were synergistically upregulated by the combination of LIGHT with IL-17 (Fig. 4), again some, such as C3, BIRC3, CXCL1, CXCL6, and CSF3, were strongly expressed in ILD fibroblast clusters 12 or 11, but other transcripts were not associated with these clusters in a more biased manner (Fig. S2B). Here, C3 is linked to interstitial lung disease.