Astrocytes are known to be become reactive in Parkinson’s disease that includes neuroinflammation, and several genes implicated in Parkinson’s are expressed in both astrocytes and neurons (e.g., PARK7, SNCA, PLA2G6, ATP13A2, LRRK2, PINK1, and PARK2). This evidence concerns the gene LRRK2 and Parkinson disease.