A recent study employing the 6-OHDA mouse model of Parkinson’s with L-Dopa treatment to study the development of LID explored if astrocyte stimulation of Gq and Gi-GPCR pathways was beneficial or detrimental with regard to LID.237 The authors found that Gq DREADD activation concomitantly with L-Dopa worsened LID, whereas Gi DREADD activation improved it.237 Downstream mechanisms need to be explored and if identified could suggest astrocytic mechanisms that are potentially targetable for LID or for Parkinson’s disease. This evidence concerns the gene GNAI1 and Parkinsonism.