Infection assay results showed that mutations Mut 2 (residues 1126–1128) and Mut 3 (residues 1129–1131) in the N-terminal extension of the SH, and Mut 9 (residues 1147–1149) within the PFPH-1 domain, reduced SC2-VLP infectivity by more than 100-fold compared with wild type (WT) (Fig 2B and 2C). The gene discussed is TECR; the disease is infection.