For example, we find that while interferon-specific cytokines like IFNα1 and IFNγ are upregulated in patients with severe COVID19 for activity estimates generated using the mousse.pos (see S26 Fig) and mousse.neg (see S27 Fig) methods, there is not necessarily a strict, clustered separation between differentially expressed markers by disease severity. This evidence concerns the gene IFNA1 and COVID-19.