PDK1 and osteosarcoma: In addition, we compared the expression of PDK1 with that of classical osteosarcoma markers and found parallel expression patterns, suggesting that PDK1 may serve as a complementary or alternative prognostic biomarker for osteosarcoma.These results suggest that PDK1 plays a critical role in regulating the glycolytic metabolism of osteosarcoma cells and may serve as a potential therapeutic target.