Among the genes that were predicted by the model with high scores (threshold of 0.7), that genes showed significant differential expression in the transcriptome, and those were significantly different in both LUAD and LUSC, we found that some potential targets such as GPX2 (Figure 4d), PRR13, and APOC1, which are highly expressed in cancer samples of LUAD and LUSC (Figure S17b,c, Supporting Information), were significantly downregulated under the intervention of all these three NP (Figure S17a, Supporting Information). The gene discussed is GPX2; the disease is cancer.