TGFB1 and inflammatory bowel disease: Moreover, the overactivation of Th1/Th17 responses and the damage to Foxp3+ Treg cells have been described as key pathogenic mechanisms of IBD.[72] Treg‐mediated immune suppression through the secretion of inhibitory cytokines such as TGF‐β and IL‐10 is of great significance in controlling IBD.