Chemokines such as CXCL1, CXCL2, and CCL20 are elevated in IBD patients and promote the infiltration of neutrophils and Th17 cells, thereby perpetuating mucosal damage.[64] Our RNA‐seq data showing increased chemokine signaling suggest that DSS‐induced colitis recapitulates this chemokine‐driven leukocyte trafficking, further exacerbating disease severity. The gene discussed is CXCL2; the disease is colitis.