These anti‐inflammatory effects contribute to the improvement of colitis symptoms through several mechanisms, including downregulation of pro‐inflammatory cytokines, reduction of immune cell infiltration, protection of the mucosal barrier, modulation of gut microbiota composition and BA metabolism, enhancement of SCFA production, and rebalancing of CD25+Foxp3+ Treg and IL‐17+CD4+ T cell responses. Here, CD4 is linked to colitis.