MPO, which is predominantly expressed by neutrophils, promotes the formation of reactive molecules such as hypochlorous acid at sites of inflammation and plays a critical role in the pathogenesis of IBD.[47] In this study, MPO levels were significantly elevated in the colonic tissues of DSS‐treated mice but were notably reduced following HNVs treatment, underscoring the anti‐inflammatory potential of HNVs in the context of IBD. Here, MPO is linked to inflammatory bowel disease.