In glioblastoma, TLS are rich in B‐ and T‐cells, as thoroughly characterized with CD20, CD4, CD8.[60] As TLS can be preliminary defined with the pan leukocyte marker CD45,[60] we asked whether there could be a link between the presence of CD45+ aggregates and the presence of LEC‐like cells, as assessed by LYVE1 immunostaining. This evidence concerns the gene CD4 and glioblastoma.