Untensed fibronectin fibers were identified within MVPs of human glioblastoma tissue cryosections (Figure 1A), whereas the surrounding soft brain parenchyma remained largely fibronectin‐free.[35] Building on our recent discovery that low‐tension fibronectin fiber tracks in murine breast tumors are densely populated with M2 macrophages,[56] we further explored whether reduced fibronectin fiber tension correlates with the spatial distribution of infiltrating immune cells (Figure 1A). This evidence concerns the gene FN1 and glioblastoma.