TG2 in its closed conformation has higher affinity to fibronectin when its fibers have lost their tension, either via proteolytic cleavage our due to collagen fibers taking over as force‐bearing elements.[75] Our data show that enhanced ECM binding of TG2 in regions enriched in untensed fibronectin fibers, namely in ‐MVPs, is not observed though (Figure S10, Supporting Information), suggesting that TG2 may exist primarily in its open, active state, which is unaffected by fiber strain.[75] Multiple independent studies corroborate that active TG2 is enriched in glioblastoma.[79, 105]. Here, TGM2 is linked to glioblastoma.