FN1 and neoplasm: The ECM is an inherent and dynamic component of the tumor microenvironment, orchestrating cell fate through extensive, bidirectional crosstalk between cells and the ECM itself—a process modulated by integrins and other ECM‐binding proteins.[7, 8, 11, 14] While excessive collagen fiber deposits can be visualized label‐free using Second Harmonic Generation (SHG) microscopy in biopsy samples,[30] other ECM proteins—primarily secreted by endothelial cells and pericytes—include collagen IV (COL4A1), elastin, laminin, and fibronectin.