In GLMM model, age (OR = 1.27, CI: 1.03–1.55, P = 0.023), nadir CD4+ cell count (OR = 0.81, CI: 0.66 – 0.99, P = 0.044) and polypharmacy (OR = 3.44, CI: 1.98–5.95, P < 0.001) were associated with CF after adjustment for time since HIV diagnosis, multimorbidity, depression and cumulative exposure to RAL (Table 2B). This evidence concerns the gene CD4 and major depressive disorder.