CD4 and depressive symptom measurement: In GLMNM model, age (OR = 1.27, CI: 1.02–1.55, P = 0.022), nadir CD4+ cell count (OR = 0.81, CI: 0.66–0.99, P = 0.042) and polypharmacy (OR = 3.47, CI: 2.00–6.00, P < 0.001) were associated with CF after adjustment for time since HIV diagnosis, multimorbidity, depression and cumulative exposure to DTG (Table 2A).