IFNG and tuberculosis: To evaluate the performance QIAreach against QFT-Plus as a reference, we determined the: i) prevalence of TBI, ii) total concordance, iii) predictors of discordant results, and iv) relationship between QIAreach time to results and IFN-γ response (QFT-Plus) levels among household contacts (HHCs) of people with TB (PWTB) in Lesotho, South Africa, and Tanzania.