CDKN2A and gonorrhea: Molecular profiling studies reveal that adult PAs are less frequently driven by the canonical KIAA1549–BRAF fusion common in pediatric cases (present in up to 98% of pediatric PAs [12, 25], and instead show a more diverse range of MAPK pathway alterations, including BRAFV600E mutations and FGFR1 aberrations [26, 27], which are linked to poorer progression-free survival, particularly when co-occurring with CDKN2A/B deletions [28, 29].