Mechanistically, in a direct crosstalk, platelet recruitment by tumor cells can be facilitated by the interaction of platelet P‐selectin with glycoprotein s‐Le (x) on mucin‐producing carcinomas or sulfatides expressed on specific cancer cells, while the interactions also more strengthen with interplays between platelets GPIb‐IX‐V, GPIIb‐IIIa (αIIbβ3), and tumor cell integrin αvβ3 [148]. The gene discussed is ART4; the disease is neoplasm.