Of note, HYP‐PDT has been reported to trigger ICD through the release of danger‐associated molecular patterns (DAMP: e.g., CRT, ATP, HSP70/90) immunological signals, capable of recruiting and activating innate immune cells (macrophages, dendritic cells), which subsequently promote tumor antigen presentation in secondary lymphoid organs (e.g., spleen and lymph nodes) to activate cytotoxic CD8+ T‐cells against both locally irradiated and distant non‐irradiated tumors [56, 59, 175, 176, 177]. The gene discussed is CD8A; the disease is neoplasm.