According to this study, EGFR inhibitors such as gefitinib and afatinib demonstrated high tumor-to-non-tumor IC50 ratios (approximately 400 and 100, respectively) in vitro and suppressed tumor growth in xenograft FANCA-HNSCC in vivo models without inducing significant hematopoietic toxicity in FANCA-deficient mice. The gene discussed is FANCA; the disease is neoplasm.