More recent re-analysis of TCGA dataset showed that up to 13% of HPV-negative sporadic HNSCC cases harbored deletions in FANCV/MAD2L2, FANCR/RAD51, FANCU/XRCC2, as well as ALDH2, a known FA disease modifier. The gene discussed is XRCC2; the disease is head and neck squamous cell carcinoma.