Isogenic HNSCC cell lines with and without a proficient FA pathway showed that the loss of the FA gene function resulted in an increase in vimentin expression, intercellular projections, and invasiveness, which was associated with increased activities of DNA-dependent protein kinase (DNA-PK) and Rac1 GTPase [74], suggesting that the FA pathway is required to maintain epithelial cell morphology with intact cellular organization. This evidence concerns the gene FANCA and head and neck squamous cell carcinoma.