Also, mice transgenic for human IL-37 showed reduced joint swelling and consequently inflammation in SCW arthritis.23 Moreover, in the collagen-induced arthritis (CIA)-model less cartilage damage was observed in presence of IL-37.34 In this model, IL-37-adenovirus or control-adenovirus were intra-articularly injected into knee joints of DBA/1J mice 17 and 23 days after first immunization. The gene discussed is IL37; the disease is arthritic joint disease.