In line with our finding, mice treated with recombinant-IL-37 showed reduced joint swelling, another measure for joint inflammation, in SCW-induced arthritis.23 A difference between our study and the SCW-induced arthritis model is that in our study, IL-37 treatment was started after induction of the CiOA-model, whereas in the SCW-induced arthritis model IL-37-treatment was started prior to induction of the model. Here, IL37 is linked to Arthritis.