EWSR1 and amyotrophic lateral sclerosis: Since cytoplasmic mislocalization of nuclear proteins is a hallmark of neurodegenerative diseases, particularly ALS, we performed IF staining of different RNA binding proteins (RBPs) associated with ALS and other neurodegenerative diseases (Figure 6C, S6), namely FUS, EWSR1 (Ewing sarcoma breakpoint region 1) and hnRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1) (H. J. Kim et al. 2013; Vance et al. 2013).