Because of the known relationship between lysosomal dysfunction and FTD/ALS pathophysiology (Root et al., 2021; Rhinn et al., 2022; Hung and Patani, 2024; Wallings et al., 2019; Talaia et al., 2024; Ling et al., 2019; Beckers et al., 2021), we focused on the relationship between TDP-43 levels, lysosomal biology, and BORC. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.