The serine/threonine Protein Kinase D family (PKD, comprising PKD1, PKD2, and PKD3) is involved in several cellular processes, including cell migration,1,2 proliferation,3,4,5 protein transport,6,7,8,9 secretion10,11 and EMT,12 and thus has a key role in tumor progression. This evidence concerns the gene PRKD1 and neoplasm.